How to use protect in a sentence. To protect someone or something means to prevent them from being harmed or damaged. For example, you might get a flu shot to protect against the flu virus. Learn more. pro•tect /prəˈtɛkt/ v. PROTECT definition: to defend or guard from attack, invasion, loss, annoyance, insult, etc. PROTECT meaning: 1 : to keep (someone or something) from being harmed, lost, etc. usually + against The meaning of PROTECT is to cover or shield from exposure, injury, damage, or destruction : guard. When you protect something, in a way you’re covering it or shielding it from harm. [no object] The police are there to protect.

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